液质校准用利血平/甲醇水标准溶液的研制

doi:10.12060/j.issn.1000-7202.2014.05.15

宇航计测技术

液质校准用利血平/甲醇水标准溶液的研制

李艳玲¹；周彤¹；冀克俭¹；刘元俊¹；高岩立¹；赵晓刚¹；邓卫华¹；邵鸿飞¹

1、中国兵器工业集团第五三研究所，济南 250031

出版日期:2014-10-15 发布日期:2014-10-15

Prepareation of Standard Solution of Reserpine in Methanol Aqueous for LC-MS Calibration

LI Yan-ling¹；ZHOU Tong¹；JI Ke-jian¹；LIU Yuan-jun¹；GAO Yan-li¹；ZHAO Xiao-gang¹

1、CNGC institute 53, Jinan 250031

Online:2014-10-15 Published:2014-10-15

摘要/Abstract

摘要： 研制了液相色谱-质谱（LC-MS）校准用利血平/甲醇水溶液标准物质。采用准确可靠的方法对利血平粉末纯度进行定值，用已确定值的利血平为溶质，甲醇水为溶剂，用重量-容量法制得利血平/甲醇水溶液。分别用F检验和回归曲线法对均匀性和稳定性进行考察，对定值结果的不确定度进行了评定。结果表明研制的利血平/甲醇水溶液标准物质具有良好的均匀性和稳定性，标准相对扩展不确定度为3%（k=2）。

关键词: 利血平, 液质校准, 标准溶液

Abstract: Standard solution of reserpine in methanol aqueous for LC-MS calibration was developed. The puriety of reserpine powder was certified with credible methods. The standard solution was prepared by weight-volumetric method using the reserpine powder as solute and the methanol aqueous as solvent. Uniformity and stability of standard solution was analyzed by F test and regression curve method respectively, the uncertainty of the results was evaluated. The result showed that uniformity and stability of the standard solution of reserpine in methanol aqueous was better, the relative standard uncertainty of concentration was 3%（k=2）.

Key words: Reserpine, LC-MS Calibration, Standard solution

李艳玲；周彤；冀克俭；刘元俊；高岩立；赵晓刚；邓卫华；邵鸿飞. 液质校准用利血平/甲醇水标准溶液的研制[J]. 宇航计测技术, doi: 10.12060/j.issn.1000-7202.2014.05.15.

LI Yan-ling；ZHOU Tong；JI Ke-jian；LIU Yuan-jun；GAO Yan-li；ZHAO Xiao-gang. Prepareation of Standard Solution of Reserpine in Methanol Aqueous for LC-MS Calibration[J]. JOURNAL OF ASTRONAUTIC METROLOGY AND MEASUREMENT, doi: 10.12060/j.issn.1000-7202.2014.05.15.

液质校准用利血平/甲醇水标准溶液的研制

Prepareation of Standard Solution of Reserpine in Methanol Aqueous for LC-MS Calibration

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